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OPT 6122 Advanced Search Exercises 2017

Clinical Question (PICO):

In patients with primary open angle glaucoma, do topical medications to reduce intraocular pressure versus no treatment delay visual field defect progression?


1. Clinical Key. Search all content types for background information and images on “primary open angle glaucoma”.

From the Optometry page, click on Clinical Key.

Register and then Login with your user id and password.

Enter “primary open” in the search box and follow system prompts to select the subject heading, “primary open angle glaucoma”.

You will find background information from a variety of resources, such as, a Disease Overview from the 2017 Conn’s Current Therapy (right sidebar). The main results section in the center of the page displays an evidence based summary in First Consult, full text book chapters, and journal articles.

Move your cursor over the titles of citations in the main results section to display the icons to save, email, or print.

Under Source Type (left sidebar), click on the down arrow and select “Images”.

Click on an image you want to use for a presentation.

Click on the “add to presentation” icon.

Select or create a new presentation and save the image to it.

Pull down the menu under your login name and click on “presentations”.

Click on the saved image and click on “Export”.

The image will be saved to PowerPoint along with the copyright information. Watch the Clinical Key video on the Optometry A-Z page to review the above steps anytime.

Close the PowerPoint presentation.


2. Clinical Key. Locate randomized control trials and systematic reviews on treatment of “primary open angle glaucoma”.

In the Clinical Key search box, add “eye drops” to the original search for “primary open angle glaucoma” and press the search icon.

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Under Source Type, click the box next to “Journal Articles” and the button beside “Full text and MEDLINE”.

Check the box beside “Randomized Control Trials”.

Scroll the citations and click on the download PDF icon to display full text that is available in Clinical Key.

Check the boxes beside interesting citations that are not available in full text in Clinical Key, e.g., articles from Experimental Eye Research and Journal of Glaucoma. Scroll to the top of the main results section. The number of citations you have checked appears beside the icons to save, email, or print. Click the icon to print citations you have marked:

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Save the printout and use it to locate full text in other resources (See examples in OPT 6111 Basic exercises for this course).

Under Source Type, uncheck “Randomized Control Trials”.

Check the box beside “Systematic Reviews”

Scan the list of systematic reviews. Click on the download PDF icon to display full text of systematic reviews published in journals, e.g., Survey of Ophthalmology.

Save and print the citation to a systematic review published in the Cochrane Library of Systematic Reviews. You can locate the full text of it in other resources (see exercise No. 5 below).

{Reminder: A systematic review is a critical assessment of existing evidence that addresses a focused clinical question, includes a comprehensive literature search, appraises the quality of studies, and reports results in a systematic manner. If the studies report comparable quantitative data and have a low degree of variation in their findings, a meta-analysis can be performed to derive a summary estimate of effect.}


3. Clinical Key First Consult. Search for an evidence based summary on “primary open angle glaucoma”.

Uncheck the box beside “Systematic Reviews”. Delete “eye drops” in the search box and press the search icon to return to your original search for “primary open angle glaucoma”.

Under FIRST CONSULT, click on “Primary open-angle glaucoma” to open the evidence summary.

Scroll through the sections from the left sidebar. Under “Treatment”, click on “Medications”.

Comments and summaries on medications will be followed by an “Evidence” section where RCTs and Systematic Reviews will be summarized and “graded” with an evidence level, e.g., 1 or 2.

Links are provided to the list of references with complete citations to the articles and systematic reviews.

Logout of Clinical Key and return to the Optometry web page.


4. UpToDate. Search for an evidence based summary on treatment of “primary open angle glaucoma”.

From the Optometry Web Page, click on “UpToDate”.

Enter “primary open angle glaucoma”. From the list of summaries, select “Open-angle glaucoma: Treatment”.

At the top of the summary, note the dates of the latest literature review and topic update.

Scan the summary and read the section on “Pharmacologic Therapy”.

From the left sidebar, click on “Summary and Recommendations”.

Does this section provide answers to the clinical question?

How is “Grade1B” defined? --- Watch the UpToDate video for an overview of "Graded Recommendations"

Are complete references provided to studies cited in the literature review that enable you to consult the original data?

Approximately how many minutes did it take for you to find an answer to the clinical question?

Return to the Optometry web page.


5. Cochrane Systematic Reviews. Locate the full text of the systematic review from your Clinical Key search on “primary open angle glaucoma”.

From the Optometry web page, click on Cochrane Systematic Reviews.

Click on “EBM Reviews – Cochrane Database of Systematic Reviews”.

At the top of the page, click on “My Account”. Login with your personal user id and password. Click on “Search”.

Select “title” and enter “neuroprotection for treatment of glaucoma in adults” and press Search.

Click on “EBM Full Text” and click on “Article as PDF”.

Scan the objectives, search methods, selection criteria, main results, and authors’ conclusions from the abstract.

Scroll to the top of the PDF. At the top left hand corner, click on the “My Projects” icon.

Add to existing projects, or create a new one.

Return to Ovid search results.

At the top of the page, from the blue bar, click on “Cochrane”.

A list displays of all of the Cochrane research groups. Scroll down to “Eyes and Vision Group” and click on “table of contents”. There are currently 237 Cochrane reviews published by this group.

Scroll the list and select additional relevant reviews to “add to my projects”.

Logoff Ovid and return to the Optometry web page.


6. Ovid MEDLINE. Find articles published in the journal, Optometry and Vision Science, that discuss use of hydrogel contact lenses for controlled drug delivery.

From the Optometry web page, click on the link to MEDLINE

Click on Ovid MEDLINE ® Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE ® Daily and Ovid MEDLINE ® 1946-present.

From the search box, enter “hydrogel contact lens” and press Search.

Note the subject heading is “contact lenses, hydrophilic”.

Click the box next to the subject heading and click the box under “explode”.

Click the box next to the keyword “hydrogel contact lens” and press Continue.

From the search box, enter “drug delivery” and press Search.

Note the subject headings are “drug carriers” or “drug delivery systems”. Click the boxes next to each subject heading and click the boxes under “explode”.

Click the box next to the keyword “drug delivery” and press Continue.

From the search page, select “Journal” and enter “optometry and vision science” in the search box.

Click “search for selected items”.

From the search box, enter 1 and 2 and 3 and press Search.

Display the eight citations. All are available in Ovid full text.

Note that several of the articles appear in the same volume and issue of the journal.

Return to the Optometry web page.


7. Science Direct. Search for a full text article on the use of “hydrogel contact lenses for controlled drug delivery”.

From the Optometry web page, click on Science Direct.

Click on “Advanced Search”.

Enter “hydrogel contact lenses” in the first search box and “drug delivery” in the second.

Refine your search. Check “journals”, “subscribed publications”, and “open access articles”.

Choose “years” 2015-present.

Scan the retrieval. You will notice many journal titles in pharmaceutics and biomedicine. All are in full text. Science Direct does not include MEDLINE but is useful to find articles published in Elsevier scientific and technical journals. It also contains issues of the journals included in Clinical Key that were published before 2007.

Return to the Optometry web page.


8. Visionet. Search for articles that discuss “vision therapy”.

From the Optometry web page, click on “Visionet”.

Enter “vision therapy” and press Submit.

The list of citations will not include abstracts or full text.

Journals that do not appear in Clinical Key or in MEDLINE will be included.

Select relevant articles and print the list.

Return to the Optometry web page.

Follow the steps to locate full text of the articles you selected in Visionet using the “Optometry eJournals A-Z by Title” page.






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Last update: May 25, 2017